|
KMID : 1197720160090030144
|
|
대한파킨슨병 및 이상운동질환 학회지
2016 Volume.9 No. 3 p.144 ~ p.151
|
|
|
Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson’s Disease
|
|
Kwon Kyum-Yil
Pyo Seon-Jong
Lee Hye-Mi
Seo Woo-Keun
Koh Seong-Beom
|
|
|
Abstract
|
|
|
Objective: We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD).
Methods: We selected drug-naive PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2.
Results: Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.
Conclusion: This exploratory study showed that baseline cognition in drug-naive PD patients might be related to the visit-to-visit variability of DBP and/or HR.
|
|
|
KEYWORD
|
|
|
Parkinson’s disease, blood pressure, heart rate, variability, cognition
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|